International Agency for Research on Cancer (IARC) - Summaries & Evaluations
DIBENZO[a,e]FLUORANTHENE
VOL.: 32 (1983) (p. 321)
CAS No.: 5385-75-1
Chem. Abstr. Name: Dibenz(a,e)aceanthrylene
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Dibenzo[a,e]fluoranthene was tested for carcinogenicity in one
study by skin application to mice and produced skin tumours. It was
also tested in the mouse-skin initiation-promotion assay and was
active as an initiator.
Dibenzo[a,e]fluoranthene was tested in mice by subcutaneous
administration and produced sarcomas at the injection site.
No data on the teratogenicity of this chemical were available.
No data were available to evaluate the activity of
dibenzo[a,e]fluoranthene in short-term tests.
5.2 Human data
Dibenzo[a,e]fluoranthene is present as a minor component of the
total content of polynuclear aromatic compounds in the environment.
Human exposure to dibenzo[a,e]fluoranthene occurs primarily through
the smoking of tobacco; it may also occur through inhalation of
polluted air and by ingestion of food and water contaminated by
combustion effluents.
5.3 Evaluation
There is limited evidence that dibenzo[a,e]fluoranthene is
carcinogenic to experimental animals.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 61: Group 3)
Synonym
- 2,3,5,6-Dibenzofluoranthene
Last updated: 17 April 1998